Part:BBa_K3955105
tANK6 peptide fused with slp_mod signal peptide
tANK6 is a tandem peptide designed for inhibition of amyloid beta aggregation [1,2]. It's non-tandem counterpart has also shown to have inhibitory effects on curli fiber elongation [3].
SLPmod is a signal peptide for secretion and an existing part in the registry: https://parts.igem.org/Part:BBa_K3183008 SLPmod has been shown to be effective in L. lactis [4].
References 1. Klein A, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M et al. Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers. ACS Chemical Neuroscience. 2017;8(9):1889-1900.
2. Schartmann E, Schemmert S, Niemietz N, Honold D, Ziehm T, Tusche M et al. In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease. Journal of Alzheimer's Disease. 2018;64(3):859-873.
3. Perov S, Lidor O, Salinas N, Golan N, Tayeb- Fligelman E, Deshmukh M et al. Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents. PLOS Pathogens. 2019;15(8):e1007978.
4. Fernandez A, Horn N, Wegmann U, Nicoletti C, Gasson M, Narbad A. Enhanced Secretion of Biologically Active Murine Interleukin-12 by Lactococcus lactis. Applied and Environmental Microbiology. 2009;75(3):869-871.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
| None |